RMeS (UMR Inserm U1229)

Regenerative Medicine and Skeleton

The RMeS laboratory, a joint research unit (Inserm, University of Nantes, Oniris), was created on 1 January 2017 and is headed by Jerome Guicheux.

The RMeS laboratory is a centre of excellence and a national leader in skeletal ageing and regenerative medicine. Its themes range from the study of the mechanisms governing the development, growth and ageing of bone and joint cartilage to the development of innovative 4R (Replacement, Repair, Regeneration, Reprogramming) skeletal treatment strategies.

The RMeS laboratory is organised into 2 independent research teams: REJOINT and REGOS. Within each team, there is a strong link between fundamental research and clinical applications, thanks to the presence of biologists, physical chemists and clinicians.

The REJOINT team ("skeletal physiopathology and joint regenerative medicine"), led by J. Guicheux, is dedicated to studying the physiology, development and ageing of joint tissues. This team also focuses on exploiting the properties of stem cells and innovative hydrogels for cartilage regenerative medicine.

The REGOS team ("Regenerative medicine of bone tissues") team, led by P. Weiss, focuses on the molecular aspects of bone ageing and pathophysiology, and is developing hybrid biomaterials for bone regenerative medicine.

The RMeS laboratory is organised around 4 technical platforms:

• Physical chemistry
• Cell Biology
• Molecular Biology
• Electron Microscopy, Microcharacterisation, Morphohistology and Functional Imaging (SC3M)

• Joint tissues: physiology, development and ageing

This theme also focuses on exploiting the properties of stem cells and innovative hydrogels for cartilage regeneration medicine.

• Bone tissue: molecular aspects of ageing and bone pathophysiology.

This theme is also developing hybrid biomaterials for bone regeneration medicine.

Director of the unit:

Pr Jérôme GUICHEUX

Oniris referral:

Pr Olivier GAUTHIER